![]() The work described here was supported iiĦ in part by grant funding from The United States Department of Veterans Affairs (VA Merit Award # 1I01BX and VA Research Career Scientist Award to Timothy Hoffman), The National Cancer Institute (NCI-RO1 Award # CA222293) and The Society of Nuclear Medicine and Molecular Imaging (2018 Bradley-Alavi Student Fellowship to Nkemakonam Okoye). Truman Memorial VA Hospital for providing the necessary facilities, equipment and financial support for my research. Thank you to the University of Missouri-Columbia (MU), MU Department of Chemistry, MU Research Reactor (MURR), and the Research Division at the Harry S. ![]() Also, I will like to acknowledge present and past members of the Jurisson research group for their support and for providing an intellectually stimulating environment during my studies. Wei Wycoff (NMR facility), and members of the radiopharmaceutical group at MURR (Mary Embree, Marina Kuchuk and Daniel Oconnor). John Lydon (help with HPGe studies and 105 Rh production), Dr. Fabio Gallazzi (LC-MS facility), James Guthrie (ICP-MS facility at MURR), Dr. I will also like to thank other individuals that contributed to the success of my research including Dr. Gary Baker, provided very thoughtful insights that assisted me in critically thinking about my research. The members of my graduate committee, Dr. Truman VA Hospital very memorable and I am truly grateful. Tammy and Ashley made the times I spent over in the Hoffman research labs at the Harry S. Also, special thanks to Ashley Berendzen for her contributions to the mice SPECT/CT imaging studies. I will like to specially acknowledge Tammy Rold for her contributions towards the in vitro cell studies and in vivo mice studies described in this dissertation. I owe the success of the research described in this dissertation to their dedication in nurturing me into a competent scientist by patiently teaching me the skills and expertise needed to be successful in my research. Timothy Hoffman for their incredible support, encouragement, mentorship and guidance throughout my graduate studies. BakerĤ Dedication This dissertation is dedicated to my lovely parents, Sir Josiah Okoye and Lady Charity Okoye, for their selfless sacrifice in ensuring that I got a good education.ĥ Acknowledgments I am very grateful to my advisors, Dr. Okoye, a candidate for the degree of Doctor of Philosophy in Chemistry, and hereby certify that, in their opinion, it is worthy of acceptance. Okoye 2019 All Rights Reservedģ The undersigned, appointed by the dean of the Graduate School at the University of Missouri-Columbia, have examined the dissertation entitled Synthesis and Preclinical Evaluation of Peptide Receptor-targeted Diagnostic and Therapeutic Radiopharmaceuticals for Prostate Cancer presented by Nkemakonam C. Hoffman MAY 2019Ģ Copyright by Nkemakonam C. 1 SYNTHESIS AND PRECLINICAL EVALUATION OF PEPTIDE RECEPTOR-TARGETED DIAGNOSTIC AND THERAPEUTIC RADIOPHARMACEUTICALS FOR PROSTATE CANCER A Dissertation presented to the Faculty of the Graduate School at the University of Missouri-Columbia In partial fulfillment of the requirements for the degree Doctor of Philosophy Submitted by NKEMAKONAM CHUKWUEBUKA OKOYE Under the Supervision of Professor Silvia S.
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